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Article

Detecting and characterizing genomic signatures of positive selection in global populations.

American journal of human genetics - 6 Jun 2013

Liu Xuanyao, Ong Rick Twee-Hee, Pillai Esakimuthu Nisha, Elzein Abier M, Small Kerrin S, Clark Taane G, Kwiatkowski Dominic P, Teo Yik-Ying

Abstract excerpt

Natural selection is a significant force that shapes the architecture of the human genome and introduces diversity across global populations. The question of whether advantageous mutations have arisen in the human genome as a result of single or multiple mutation events remains unanswered except for the fact that there exist a handful of genes such as those that confer lactase persistence, affect skin...

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Identifiers

PMID: 23731540
DOI: 10.1016/j.ajhg.2013.04.021
PMCID: PMC3675259

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