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Article

Identifying recent adaptations in large-scale genomic data.

Cell - 14 Feb 2013

Grossman Sharon R, Andersen Kristian G, Shlyakhter Ilya, Tabrizi Shervin, Winnicki Sarah, Yen Angela, Park Daniel J, Griesemer Dustin, Karlsson Elinor K, Wong Sunny H, Cabili Moran, Adegbola Richard A, Bamezai Rameshwar N K, Hill Adrian V S, Vannberg Fredrik O, Rinn John L, Lander Eric S, Schaffner Stephen F, Sabeti Pardis C

Abstract excerpt

Although several hundred regions of the human genome harbor signals of positive natural selection, few of the relevant adaptive traits and variants have been elucidated. Using full-genome sequence variation from the 1000 Genomes (1000G) Project and the composite of multiple signals (CMS) test, we investigated 412 candidate signals and leveraged functional annotation, protein structure modeling, epigenetics, and...

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Identifiers

PMID: 23415221
DOI: 10.1016/j.cell.2013.01.035
PMCID: PMC3674781

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TLR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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