Article
RAD51 135G>C polymorphism and risk of familial breast cancer in a South American population.
Cancer genetics and cytogenetics - 1 Oct 2007
Jara Lilian, Acevedo Monica L, Blanco Rafael, Castro Victor G, Bravo Teresa, Gómez Fernando, Waugh Enrique, Peralta Octavio, Cabrera Elsa, Reyes José M, Ampuero Sandra, González-Hormazábal Patricio
Abstract excerpt
Several studies have reported that mutations in genes involved in maintenance of genome integrity may be responsible for increased cancer risk. Human RAD51, known to function in DNA repair, interacts with a number of proteins implicated in breast cancer (BC), including BRCA1 and BRCA2. Few studies have investigated the role of RAD51 gene variations in familial BC. To detect potential novel gene defects that may...
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