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Article

Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation

1 Apr 2020

Abstract excerpt

BACKGROUND: Hypertrophic scar (HS) is characterized by the increased proliferation and decreased apoptosis of myofibroblasts. Myofibroblasts, the main effector cells for dermal fibrosis, develop from normal fibroblasts. Thus, the stimulation of myofibroblast apoptosis is a possible treatment for HS. We aimed to explore that whether over-activated myofibroblasts can be targeted for apoptosis by anticancer drug...

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PMID: 32251998
DOI: 10.1016/j.ebiom.2020.102715

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