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Article

Corneal epithelium in keratoconus underexpresses active NRF2 and a subset of oxidative stress-related genes

14 Oct 2022

Abstract excerpt

Keratoconus (KC) is a multifactorial progressive ectatic disorder characterized by local thinning of the cornea, leading to decreased visual acuity due to irregular astigmatism and opacities. Despite the evolution of advanced imaging methods, the exact etiology of KC remains unknown. Our aim was to investigate the involvement of corneal epithelium in the pathophysiology of the disease. Corneal epithelial samples...

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PMID: 36240204
DOI: 10.1371/journal.pone.0273807

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