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Article

Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation.

The Journal of biological chemistry - 12 Dec 2008

Fox Keith E, Colton Lillester A, Erickson Paul F, Friedman Jacob E, Cha Hyuk C, Keller Pernille, MacDougald Ormond A, Klemm Dwight J

Abstract excerpt

Cyclin D1 expression is elevated and Wnt10b is repressed by cAMP during the first few hours of adipogenesis. cAMP-responsive element-binding protein (CREB) is a primary target for cAMP signaling, and we have shown that activation of CREB promotes adipogenesis and adipocyte survival. Here we tested the impact of CREB on expression of cyclin D1 and wingless-related mouse mammary tumor virus integration site 10b...

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Share to 3T3-L1 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18957421
DOI: 10.1074/jbc.M806423200
PMCID: PMC2596384

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