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Article

Thyroid hormone and COUP-TF1 regulate kallikrein-binding protein (KBP) gene expression.

Endocrinology - 1 Mar 2011

Liu Yan-Yun, Nakatani Teruyo, Kogai Takahiko, Mody Kaizeen, Brent Gregory A

Abstract excerpt

Kallikrein-binding protein (KBP) is a component of the kallikrein-kinin system that mediates vasodilation and inhibits tumor growth by antagonizing vascular endothelial growth factor-mediated angiogenesis. We demonstrate that KBP gene expression is repressed by T(3) and modulated by the orphan nuclear receptor, chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1). In hypothyroid mice, KBP mRNA...

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Identifiers

PMID: 21266512
DOI: 10.1210/en.2010-0580
PMCID: PMC3040047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Thyroid hormone and COUP-TF1 regulate kallikrein-binding protein (KBP) gene expression.PMID 21266512Read ↗

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