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Article

Statistical method on nonrandom clustering with application to somatic mutations in cancer.

BMC bioinformatics - 7 Jan 2010

Ye Jingjing, Pavlicek Adam, Lunney Elizabeth A, Rejto Paul A, Teng Chi-Hse

Abstract excerpt

BACKGROUND: Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a consequence of genomic instability and high levels of proliferation, many passenger mutations that do not contribute to the cancer phenotype arise alongside mutations that drive oncogenesis. While several approaches have been developed to...

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Identifiers

PMID: 20053295
DOI: 10.1186/1471-2105-11-11
PMCID: PMC2822753

Genes

BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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