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Article

Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2017

Jin Yu, Xie Yi, Ostriker Allison C, Zhang Xinbo, Liu Renjing, Lee Monica Y, Leslie Kristen L, Tang Waiho, Du Jing, Lee Seung Hee, Wang Yingdi, Sessa William C, Hwa John, Yu Jun, Martin Kathleen A

Abstract excerpt

OBJECTIVE: Drug-eluting stent delivery of mTORC1 (mechanistic target of rapamycin complex 1) inhibitors is highly effective in preventing intimal hyperplasia after coronary revascularization, but adverse effects limit their use for systemic vascular disease. Understanding the mechanism of action may lead to new treatment strategies. We have shown that rapamycin promotes vascular smooth muscle cell differentiation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 29025710
DOI: 10.1161/ATVBAHA.117.310053
PMCID: PMC5699966

Genes

AKT2
MYOCD
FOXO4
AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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