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Article

Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2011

Horita Henrick N, Simpson Peter A, Ostriker Allison, Furgeson Seth, Van Putten Vicki, Weiser-Evans Mary C M, Nemenoff Raphael A

Abstract excerpt

OBJECTIVE: Serum response factor (SRF) is a critical transcription factor in smooth muscle cells (SMCs) controlling differentiation and proliferation. Our previous work demonstrated that depleting SRF in cultured SMCs decreased expression of SMC markers but increased proliferation and inflammatory mediators. A similar phenotype has been observed in SMCs silenced for phosphatase and tensin homolog (PTEN),...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

Share to Proto-Oncogene Proteins c-fos

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Source

Open in PubMed Open full text

Identifiers

PMID: 21940949
DOI: 10.1161/ATVBAHA.111.233585
PMCID: PMC3220738

Genes

SRF
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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