Article
Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN.
Circulation - 16 Mar 2004
Mourani Peter M, Garl Pamela J, Wenzlau Janet M, Carpenter Todd C, Stenmark Kurt R, Weiser-Evans Mary C M
Abstract excerpt
BACKGROUND: At distinct times during embryonic development and after vascular injury, smooth muscle cells (SMCs) exhibit a highly proliferative, serum-independent growth phenotype. The aim of the present study was to evaluate the functional role of S6 ribosomal protein (S6RP) and upstream positive and negative regulators in the control of SMC serum-independent growth. METHODS AND RESULTS: We previously reported...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.