Article
A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro.
Bone - 1 Aug 2010
Hoppman Nicole, McLenithan John C, McBride Daniel J, Shen Haiqing, Bruder Jan, Bauer Richard L, Shaffer John R, Liu Jie, Streeten Elizabeth A, Shuldiner Alan R, Kammerer Candace M, Mitchell Braxton D
Abstract excerpt
We previously detected strong evidence for linkage of forearm bone mineral density (BMD) to chromosome 4p (lod=4.3) in a set of 29 large Mexican American families. Fibroblast growth factor binding protein 1 (FGFBP1) is a strong candidate gene for bone homeostasis in this region. We sequenced the coding region of FGFBP1 in a subset of our Mexican American study population and performed association studies with BMD...
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