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Article

Mutation analysis of KRAS in primary colorectal cancer and matched metastases by means of highly sensitivity molecular assay.

Pathology, research and practice - 1 Apr 2013

Miglio Umberto, Mezzapelle Rosanna, Paganotti Alessia, Allegrini Sara, Veggiani Claudia, Antona Jlenia, Gentilli Sergio, Monga Guido, Alabiso Oscar, Boldorini Renzo

Abstract excerpt

Mutation analysis of KRAS is needed before starting treatment with anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer (CRC). In most of the cases, testing is performed on primary tumors, assuming that KRAS mutation status does not change in metastasis although correlation studies gave conflicting results. We evaluated the KRAS status concordance rate between primary tumors and related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23538047
DOI: 10.1016/j.prp.2013.02.006

Genes

KRAS
EGFR

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