Article
Quantifying the evolution and impact of antimalarial drug resistance: drug use, spread of resistance, and drug failure over a 12-year period in Papua New Guinea.
The Journal of infectious diseases - 1 Feb 2010
Nsanzabana Christian, Hastings Ian M, Marfurt Jutta, Müller Ivo, Baea Kay, Rare Lawrence, Schapira Allan, Felger Ingrid, Betschart Bruno, Smith Thomas A, Beck Hans-Peter, Genton Blaise
Abstract excerpt
BACKGROUND. Antimalarial use is a key factor driving drug resistance and reduced treatment effectiveness in Plasmodium falciparum malaria, but there are few formal, quantitative analyses of this process. METHODS. We analyzed drug usage, drug failure rates, and the frequencies of mutations and haplotypes known to be associated with drug resistance over a 12-year period (1991-2002) in a site in Papua New Guinea....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.