Article
Rapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial use.
PloS one - 3 Jan 2007
Noranate Nitchakarn, Durand Rémy, Tall Adama, Marrama Laurence, Spiegel André, Sokhna Cheikh, Pradines Bruno, Cojean Sandrine, Guillotte Micheline, Bischoff Emmanuel, Ekala Marie-Thérèse, Bouchier Christiane, Fandeur Thierry, Ariey Frédéric, Patarapotikul Jintana, Le Bras Jacques, Trape Jean François, Rogier Christophe, Mercereau-Puijalon Odile
Abstract excerpt
BACKGROUND: Inadequate treatment practices with antimalarials are considered major contributors to Plasmodium falciparum resistance to chloroquine, pyrimethamine and sulfadoxine. The longitudinal survey conducted in Dielmo, a rural Senegalese community, offers a unique frame to explore the impact of strictly controlled and quantified antimalarial use for diagnosed malaria on drug resistance. METHODOLOGY/PRINCIPAL...
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