Article
Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea.
Malaria journal - 28 Jan 2015
Koleala Tamarah, Karl Stephan, Laman Moses, Moore Brioni R, Benjamin John, Barnadas Celine, Robinson Leanne J, Kattenberg Johanna H, Javati Sarah, Wong Rina P M, Rosanas-Urgell Anna, Betuela Inoni, Siba Peter M, Mueller Ivo, Davis Timothy M E
Abstract excerpt
BACKGROUND: In northern Papua New Guinea (PNG), most Plasmodium falciparum isolates proved resistant to chloroquine (CQ) in vitro between 2005 and 2007, and there was near-fixation of pfcrt K76T, pfdhfr C59R/S108N and pfmdr1 N86Y. To determine whether the subsequent introduction of artemisinin combination therapy (ACT) and reduced CQ-sulphadoxine-pyrimethamine pressure had attenuated parasite drug susceptibility...
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