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Article

Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals.

Drug metabolism and pharmacokinetics - 1 Jan 2009

Kudo Mutsumi, Saito Yuka, Sasaki Takamitsu, Akasaki Hitomi, Yamaguchi Yuri, Uehara Moe, Fujikawa Kiyomi, Ishikawa Masaaki, Hirasawa Noriyasu, Hiratsuka Masahiro

Abstract excerpt

Thiopurines (such as azathioprine and 6-mercaptopurine) are widely used for the treatment of patients suffering from malignancies, rheumatic disease, inflammatory bowel disease and solid organ transplant rejection. These drugs are activated and eliminated by a number of enzymes in the human body....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20045992
DOI: 10.2133/dmpk.24.557

Genes

GMPS
IMPDH1
ITPA
IMPDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20045992-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals.PMID 20045992Read ↗

Pharmacogenetic significance of inosine triphosphatase.Semantic proximity Read ↗

Distribution of Genetic Polymorphisms of Genes Implicated in Thiopurine Drugs Metabolism.Semantic proximity Read ↗

Inter-ethnic variability of three functional polymorphisms affecting the IMPDH2 gene.Semantic proximity Read ↗

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression riskSemantic proximity Read ↗

Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population.Semantic proximity Read ↗

Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Three novel single nucleotide polymorphisms of the human thiopurine S-methyltransferase gene in Japanese individuals.Semantic proximity Read ↗

Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tangoSemantic proximity Read ↗

Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies.Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT 15 Genotypes: 2018 UpdateSemantic proximity Read ↗

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese population.Semantic proximity Read ↗

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