Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tango

4 Apr 2019

Abstract excerpt

The three thiopurines used in clinical practice are mercaptopurine and its prodrug azathioprine, as well as thioguanine. Although thiopurines were initially developed as chemotherapeutic agents for the treatment of childhood leukemia, nowadays they are also prescribed in a wider spectrum of clinical use as immunosuppressors.1 More specifically, mercaptopurine and azathioprine are currently used in the treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Childhood Cancer Survivors' Quality of Life

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30945335
DOI: 10.1002/ajh.25485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tangoPMID 30945335Read ↗

Personalization of thiopurine therapy: Current recommendations and future perspectives.Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT 15 Genotypes: 2018 UpdateSemantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update.Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.Semantic proximity Read ↗

Clinical pharmacogenomics of thiopurine S-methyltransferase.Semantic proximity Read ↗

Azathioprine dose tailoring based on pharmacogenetic information: Insights of clinical implementation.Semantic proximity Read ↗

Implications of tioguanine dosing in IBD patients with a TPMT deficiencySemantic proximity Read ↗

Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods.Semantic proximity Read ↗

Understanding thiopurine methyltransferase polymorphisms for the targeted treatment of hematologic malignancies.Semantic proximity Read ↗

Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond.Semantic proximity Read ↗

An integrated triple approach - TPMT phenotype, NUDT-15 genotype, and therapeutic drug monitoring of thiopurine metabolites for optimal clinical efficacy: a case series.Semantic proximity Read ↗

Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.