Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies.

doi:10.1016/j.stemcr.2015.01.005

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Article

Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies.

Stem cell reports - 10 Feb 2015

Lachmann Nico, Ackermann Mania, Frenzel Eileen, Liebhaber Steffi, Brennig Sebastian, Happle Christine, Hoffmann Dirk, Klimenkova Olga, Lüttge Doreen, Buchegger Theresa, Kühnel Mark Philipp, Schambach Axel, Janciauskiene Sabina, Figueiredo Constanca, Hansen Gesine, Skokowa Julia, Moritz Thomas

Abstract excerpt

Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic cell types, whereas granulocyte colony-stimulating factor (G-CSF) and macrophage CSF (M-CSF) represent critical cytokines in myeloid differentiation. When this was investigated in a pluripotent-stem-cell-based hematopoietic differentiation model, IL-3/G-CSF or IL-3/M-CSF exposure resulted in the continuous generation...

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PMID: 25680479
DOI: 10.1016/j.stemcr.2015.01.005
PMCID: PMC4325194

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