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Article

Decreasing sensitivity to cytotoxic agents parallels increasing tumorigenicity in human fibroblasts.

Cancer research - 1 Apr 1991

Kinsella A R, Haran M S

Abstract excerpt

Human embryo fibroblasts of common genetic origin but exhibiting a range of phenotypes from normal to aggressively tumorigenic have been used to study resistance to the cytotoxic drugs methotrexate and N-(phosphonacetyl)-L-aspartate. Measurement of the intrinsic sensitivities of these cells to the two drugs in standard survival assays, in normal fetal bovine serum, showed increasing resistance to parallel...

Topics

Aspartic Acid
Cell Line
Cell Line, Transformed
Cell Transformation, Neoplastic
Drug Resistance
Fibroblasts
Gene Amplification
Humans
Methotrexate
Phenotype
Phosphonoacetic Acid

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PMID: 2004369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2004369-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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