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Article

Decreasing sensitivity to cytotoxic agents parallels increasing tumorigenicity in human fibroblasts.

Cancer research - 1 Apr 1991

Kinsella A R, Haran M S

Abstract excerpt

Human embryo fibroblasts of common genetic origin but exhibiting a range of phenotypes from normal to aggressively tumorigenic have been used to study resistance to the cytotoxic drugs methotrexate and N-(phosphonacetyl)-L-aspartate. Measurement of the intrinsic sensitivities of these cells to the two drugs in standard survival assays, in normal fetal bovine serum, showed increasing resistance to parallel...

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PMID: 2004369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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