Article
Evidence for distinction of the differentiation-inducing activities and cytostatic properties of 9-(2-phosphonylmethoxyethyl)adenine and a variety of differentiation-inducing agents in human erythroleukemia K562 cells.
Molecular pharmacology - 1 Nov 1996
Hatse S, De Clercq E, Balzarini J
Abstract excerpt
The acyclic nucleoside phosphonate derivative 9-(2-phosphonylmethoxyethyl) adenine (PMEA) is a strong inducer of differentiation in several tumor cell lines, including human erythroleukemia K562 cells. A PMEA-resistant K562 cell line (designated K562/PMEA-1) was selected in the presence of escala...
Topics
- Adenine
- Antineoplastic Agents
- Cell Differentiation
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Humans
- Leukemia, Erythroblastic, Acute
- Nucleosides
- Organophosphonates
- Phenotype
- Purines
- Pyrimidines
- Tritium
- Tumor Cells, Cultured