Article

Resistance Mechanisms to Methotrexate in Tumors

1996-08-01

Abstract excerpt

Abstract The mechanisms of intrinsic and acquired resistance to methotrexate (MTX) in human tumors are reviewed herein. In blasts from patients with acute lymphocytic leukemia, resistance mechanisms found are decreased uptake and increased dihydrofolate reductase (DHFR) activity. A major cause of intrinsic resistance to MTX in soft tissue sarcoma cells and in acute myelocytic leukemia appears to be a lack of drug...

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Literature Corpus work: a78dd23d-1a53-5e77-b274-cd7bee236525
DOI: 10.1634/theoncologist.1-4-223

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