Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites.

doi:10.1074/jbc.273.40.25944

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Article

Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites.

The Journal of biological chemistry - 2 Oct 1998

Tse A, Moran R G

Abstract excerpt

Mouse L1210 cell variants were selected for resistance to 5, 10-dideazatetrahydrofolate, a potent inhibitor of the first folate-dependent enzyme in de novo purine synthesis, glycinamide ribonucleotide formyltransferase. The drug-resistant phenotype selected was conditional to the folate compound...

Topics

Animals
Biological Transport
Cell Division
Drug Resistance
Feedback
Folic Acid
Hydroxymethyl and Formyl Transferases
Kinetics
Leukemia L1210
Mice
Peptide Synthases
Phenotype
Phosphoribosylglycinamide Formyltransferase
Pteroylpolyglutamic Acids
RNA, Messenger
Tetrahydrofolates
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9748271
DOI: 10.1074/jbc.273.40.25944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9748271-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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