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The synaptic muscle‐specific kinase (MuSK) complex: New partners, new functions

19 Oct 2005

Abstract excerpt

The muscle-specific kinase MuSK is part of an agrin receptor complex that stimulates tyrosine phosphorylation and drives clustering of acetylcholine receptors (AChRs) in the postsynaptic membrane at the vertebrate neuromuscular junction (NMJ). MuSK also regulates synaptic gene transcription in subsynaptic nuclei. Over the past few years, decisive progress has been made in the identification of MuSK effectors,...

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PMID: 16237673
DOI: 10.1002/bies.20305

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The synaptic muscle‐specific kinase (MuSK) complex: New partners, new functionsPMID 16237673Read ↗

Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure.Semantic proximity Read ↗

Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations.Semantic proximity Read ↗

The MuSK-BMP pathway regulates synaptic Nav1.4 localization and muscle excitabilitySemantic proximity Read ↗

The agrin/muscle‐specific kinase pathway: New targets for autoimmune and genetic disorders at the neuromuscular junctionSemantic proximity Read ↗

The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.Semantic proximity Read ↗

Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.Semantic proximity Read ↗

Mutations in MUSK causing congenital myasthenic syndrome impair MuSK–Dok-7 interactionSemantic proximity Read ↗

A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndromeSemantic proximity Read ↗

The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapsesSemantic proximity Read ↗

Developmental consequences of the ColQ/MuSK interactions.Semantic proximity Read ↗

The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.Semantic proximity Read ↗

MuSK controls where motor axons grow and form synapses.Semantic proximity Read ↗

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