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TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development

30 Dec 2009

Abstract excerpt

TDP-43 is a DNA/RNA-binding protein implicated in multiple steps of transcriptional and post-transcriptional regulation of gene expression. Alteration of this multifunctional protein is associated with a number of neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin positive inclusions. Whereas a pathological link to neurodegenerative disorders...

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PMID: 20040602
DOI: 10.1074/jbc.m109.061846

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TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic DevelopmentPMID 20040602Read ↗

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