Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease

1 Nov 2007

Abstract excerpt

TDP-43 is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member and displays a significant specificity for binding the common microsatellite region (GU/GT)n. Initially described as a regulator of HIV-1 gene expression, it has been reported in the past to affect both normal and pathological RNA splicing events. In particular, it has been shown to play a fundamental role in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17981595
DOI: 10.2741/2727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple roles of TDP-43 in gene expression, splicing regulation, and human diseasePMID 17981595Read ↗

Abnormal Splicing Events due to Loss of Nuclear Function of TDP-43: Pathophysiology and PerspectivesSemantic proximity Read ↗

TDP-43: a DNA and RNA binding protein with roles in neurodegenerative diseases.Semantic proximity Read ↗

Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and diseaseSemantic proximity Read ↗

Decoding TDP-43: the molecular chameleon of neurodegenerative diseasesSemantic proximity Read ↗

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathiesSemantic proximity Read ↗

TDP-43 proteinopathies: a new wave of neurodegenerative diseasesSemantic proximity Read ↗

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulationSemantic proximity Read ↗

Functional Significance of TDP-43 Mutations in Disease.Semantic proximity Read ↗

TDP-43 Epigenetic Facets and Their Neurodegenerative ImplicationsSemantic proximity Read ↗

The role of TDP-43 in the pathogenesis of ALS and FTLDSemantic proximity Read ↗

Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasisSemantic proximity Read ↗

Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.