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Article

TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.

Genesis (New York, N.Y. : 2000) - 1 Jan 2010

Wu Lien-Szu, Cheng Wei-Cheng, Hou Shin-Chen, Yan Yu-Ting, Jiang Si-Tse, Shen C-K James

Abstract excerpt

TDP-43 is a highly conserved and ubiquitously expressed nuclear protein. It has been implicated in the regulation of transcription, alternative splicing, translation, and neuronal plasticity. TDP-43 has also been shown to be a disease signature protein associated with several neurodegenerative diseases including amyotrophic lateral sclerosis. However, the correlation of the physiological functions of TDP-43 with...

Topics

Animals
Blotting, Western
DNA-Binding Proteins
Embryo, Mammalian
Embryonic Development
Female
Gene Expression Regulation, Developmental
Genes, Essential
Genotype
Immunohistochemistry
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Neurodegenerative Diseases

Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 20014337
DOI: 10.1002/dvg.20584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.PMID 20014337Read ↗

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