Article
Gender-specific association of methylenetetrahydrofolate reductase genotype and haplotype with the aggressiveness and prognosis of clear cell renal cell carcinoma in Japanese patients.
BJU international - 1 Aug 2010
Sakano Shigeru, Hinoda Yuji, Okayama Naoko, Kawai Yoshihisa, Ito Hideaki, Nagao Kazuhiro, Hara Takahiko, Matsuyama Hideyasu
Abstract excerpt
OBJECTIVE: To determine if the two common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, affect tumour aggressiveness or prognosis of clear cell renal cell carcinoma (CCRCC) in Japanese patients. PATIENTS AND METHODS: MTHFR C677T and A1298C polymorphisms have been reported to cause decreased enzyme activity, which reduces the quantity of methyl groups available for DNA...
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