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Article

Prognostic Relevance of Methylenetetrahydrofolate Reductase Polymorphisms for Prostate Cancer.

International journal of molecular sciences - 29 Nov 2016

Lin Victor C, Lu Te-Ling, Yin Hsin-Ling, Yang Sheau-Fang, Lee Yung-Chin, Liu Chia-Chu, Huang Chao-Yuan, Yu Chia-Cheng, Chang Ta-Yuan, Huang Shu-Pin, Bao Bo-Ying

Abstract excerpt

Folate metabolism has been associated with cancers via alterations in nucleotide synthesis, DNA methylation, and DNA repair. We hypothesized that genetic variants in methylenetetrahydrofolate reductase (MTHFR), a key enzyme of folate metabolism, would affect the prognosis of prostate cancer. Three haplotype-tagging single-nucleotide polymorphisms (SNPs) across the MTHFR gene region were genotyped in a cohort of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27916838
DOI: 10.3390/ijms17121996
PMCID: PMC5187796

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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