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Combined effects of DNA methyltransferase 1 and 3A polymorphisms and urinary total arsenic levels on the risk for clear cell renal cell carcinoma.

Toxicology and applied pharmacology - 15 Aug 2016

Yang Shu-Mei, Huang Chao-Yuan, Shiue Horng-Sheng, Pu Yeong-Shiau, Hsieh Yi-Hsun, Chen Wei-Jen, Lin Ying-Chin, Hsueh Yu-Mei

Abstract excerpt

Our previous study showed that high urinary total arsenic levels were associated with higher odds ratio (OR) for renal cell carcinoma (RCC). Single nucleotide polymorphisms (SNPs) of DNA methyltransferases (DNMTs) might influence DNMT enzyme activity associated with tumorigenesis. In this study, we investigated the association of five SNPs from DNMT1 (rs8101626 and rs2228611), DNMT3A (rs34048824 and rs1550117),...

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Share to Arsenic
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Source

Identifiers

PMID: 27292127
DOI: 10.1016/j.taap.2016.06.011

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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