Article
GSTM1 genotype is an independent prognostic factor in clear cell renal cell carcinoma.
Urologic oncology - 1 Jun 2017
Coric Vesna M, Simic Tatjana P, Pekmezovic Tatjana D, Basta-Jovanovic Gordana M, Savic-Radojevic Ana R, Radojevic-Skodric Sanja M, Matic Marija G, Suvakov Sonja R, Dragicevic Dejan P, Radic Tanja M, Dzamic Zoran M, Pljesa-Ercegovac Marija S
Abstract excerpt
PURPOSE: Owing to dual functionality of cytosolic glutathione S-transferases (GSTs), they might affect both the development and the progression of renal cell carcinoma (RCC). However, the data on the prognostic value of GST polymorphism in patients with RCC are scarce. Hence, we evaluated the effect of GST gene variants on both the risk of RCC development and the postoperative prognosis in patients with clear...
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