Article
The T309G murine double minute 2 gene polymorphism is an independent prognostic factor for patients with renal cell carcinoma.
DNA and cell biology - 1 Feb 2015
de Martino Michela, Taus Christopher, Wessely Isabelle S, Lucca Ilaria, Hofbauer Sebastian L, Haitel Andrea, Shariat Shahrokh F, Klatte Tobias
Abstract excerpt
The purpose of this study was to evaluate the association of the T309G MDM2 gene polymorphism with renal cell carcinoma (RCC) risk, pathology, and cancer-specific survival (CSS). T309G MDM2 was genotyped in 449 Caucasians, including 240 with RCC and 209 cancer-free controls. The T309G MDM2 genotype was TT in 174 (38.8%), GT in 214 (47.7%), and GG in 61 (13.6%) subjects, without any significant differences between...
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