Article
Loss of LAP2 alpha delays satellite cell differentiation and affects postnatal fiber-type determination.
Stem cells (Dayton, Ohio) - 31 Mar 2010
Gotic Ivana, Schmidt Wolfgang M, Biadasiewicz Katarzyna, Leschnik Michael, Spilka Rita, Braun Juliane, Stewart Colin L, Foisner Roland
Abstract excerpt
Lamina-associated polypeptide 2 alpha (LAP2 alpha) is a nucleoplasmic protein implicated in cell cycle regulation through its interaction with A-type lamins and the retinoblastoma protein. Mutations in lamin A/C and LAP2 alpha cause late onset striated muscle diseases, but the molecular mechanisms are poorly understood. To study the role of LAP2 alpha in skeletal muscle function and postnatal tissue homeostasis,...
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