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Article

SMN depletion impairs skeletal muscle formation and maturation in a mouse model of SMA

1 Nov 2024

Abstract excerpt

Spinal muscular atrophy (SMA) is characterized by low levels of the ubiquitously expressed Survival Motor Neuron (SMN) protein, leading to progressive muscle weakness and atrophy. Skeletal muscle satellite cells play a crucial role in muscle fiber maintenance, repair, and remodelling. While the effects of SMN depletion in muscle are well documented, its precise role in satellite cell function remains largely...

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PMID: 39505369
DOI: 10.1093/hmg/ddae162

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