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Chlamydomonas LZTFL1 mediates phototaxis via controlling BBSome recruitment to the basal body and its reassembly at the ciliary tip

26 Aug 2021

Abstract excerpt

Significance Bardet–Biedl syndrome (BBS) characteristic of blindness, obesity, and kidney anomalies is a rare human ciliopathy. BBS could result from disrupted ciliary dynamics of the BBSome, a conserved octamer of BBS proteins, which facilitates intraflagellar transport with the ciliary entry and/or removal of signaling proteins. Here, we show that LZTFL1 mediates phototaxis through balancing BBSomes available...

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PMID: 34446551
DOI: 10.1073/pnas.2101590118

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