A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.

doi:10.1016/j.neurobiolaging.2009.11.021

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Article

A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.

Neurobiology of aging - 1 Mar 2011

Krüger Rejko, Sharma Manu, Riess Olaf, Gasser Thomas, Van Broeckhoven Christine, Theuns Jessie, Aasly Jan, Annesi Grazia, Bentivoglio Anna Rita, Brice Alexis, Djarmati Ana, Elbaz Alexis, Farrer Matthew, Ferrarese Carlo, Gibson J Mark, Hadjigeorgiou Georgios M, Hattori Nobutaka, Ioannidis John P A, Jasinska-Myga Barbara, Klein Christine, Lambert Jean-Charles, Lesage Suzanne, Lin Juei-Jueng, Lynch Timothy, Mellick George D, de Nigris Francesa, Opala Grzegorz, Prigione Alessandro, Quattrone Aldo, Ross Owen A, Satake Wataru, Silburn Peter A, Tan Eng King, Toda Tatsushi, Tomiyama Hiroyuki, Wirdefeldt Karin, Wszolek Zbigniew, Xiromerisiou Georgia, Maraganore Demetrius M

Abstract excerpt

High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common Omi/HtrA2 variants in the Genetic Epidemiology of Parkinson's disease (GEO-PD) consortium. GEO-PD sites provided clinical and genetic data including affection status, gender, ethnicity, age at...

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Identifiers

PMID: 20036034
DOI: 10.1016/j.neurobiolaging.2009.11.021
PMCID: PMC4724437

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