Article
Genetic variation of Omi/HtrA2 and Parkinson's disease.
Parkinsonism & related disorders - 1 Nov 2008
Ross Owen A, Soto Alexandra I, Vilariño-Güell Carles, Heckman Michael G, Diehl Nancy N, Hulihan Mary M, Aasly Jan O, Sando Sigrid, Gibson J Mark, Lynch Timothy, Krygowska-Wajs Anna, Opala Grzegorz, Barcikowska Maria, Czyzewski Krzysztof, Uitti Ryan J, Wszolek Zbigniew K, Farrer Matthew J
Abstract excerpt
Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series...
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