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Article

Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization.

Brain research - 4 Mar 2010

Sharf Ruth, Guarnieri Douglas J, Taylor Jane R, DiLeone Ralph J

Abstract excerpt

Orexin (or hypocretin) has been implicated in mediating drug addiction and reward. Here, we investigated orexin's contribution to morphine-induced behavioral sensitization and place preference. Orexin-/- (OKO) mice and littermate wild-type (WT) controls (n=56) and C57BL/6J mice (n=67) were tested...

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Identifiers

PMID: 20034477
DOI: 10.1016/j.brainres.2009.12.035
PMCID: PMC2822072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20034477-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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