Article
Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin.
Pharmacology, biochemistry, and behavior - 1 Sept 2004
Hayward Michael D, Hansen Stephen T, Pintar John E, Low Malcolm J
Abstract excerpt
To test whether endogenous opioid peptides are necessary for the rewarding effects of ethanol, we examined operant oral self-administration of ethanol in mice congenic to the C57BL/6J strain but lacking expression of beta-endorphin, enkephalin or both peptides. The influences of prandial state, schedule interval and type, and ethanol concentration were all examined. Food-restricted subjects were tested in...
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