Article
Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects.
Immunogenetics - 1 Feb 2010
Klinker Matthew W, Schiller Jennifer J, Magnuson Victoria L, Wang Tao, Basken Joel, Veth Kerry, Pearce Kaela I, Kinnunen Leena, Harjutsalo Valma, Wang Xujing, Tuomilehto Jaakko, Sarti Cinzia, Ghosh Soumitra
Abstract excerpt
The onset of type 1 diabetes can occur at any age, with as many as half of all cases diagnosed after age 15. Despite this wide distribution in age at diagnosis, most genetic studies focus on cases diagnosed in childhood or during early adulthood. To better understand the genetics of late-onset type 1 diabetes, we collected a Finnish case/control cohort with all cases diagnosed between ages 15 and 40. We genotyped...
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