Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort.

Circulation. Cardiovascular genetics - 1 Apr 2009

Thompson John F, Hyde Craig L, Wood Linda S, Paciga Sara A, Hinds David A, Cox David R, Hovingh G Kees, Kastelein John J P

Abstract excerpt

BACKGROUND: Statins are effective at lowering low-density lipoprotein cholesterol and reducing risk of cardiovascular disease, but variability in response is not well understood. To address this, 5745 individuals from the Treating to New Targets (TNT) trial were genotyped in a combination of a wh...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to Atorvastatin
Share to Coronary Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heptanoic Acids

Share to Proprotein Convertase 9

Share to Proprotein Convertases

Share to Pyrroles

Share to Serine Endopeptidases

Source

Identifiers

PMID: 20031582
DOI: 10.1161/CIRCGENETICS.108.818062

Genes

PCSK9
HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20031582-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort.PMID 20031582Read ↗

An association study of 43 SNPs in 16 candidate genes with atorvastatin response.Semantic proximity Read ↗

Seventeen years of statin pharmacogenetics: a systematic review.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.Semantic proximity Read ↗

Genome-wide association of lipid-lowering response to statins in combined study populations.Semantic proximity Read ↗

Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.Semantic proximity Read ↗

GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study.Semantic proximity Read ↗

Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein-Related Measures.Semantic proximity Read ↗

Pharmacogenomics of statin response.Semantic proximity Read ↗

Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.Semantic proximity Read ↗

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.Semantic proximity Read ↗

A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering.Semantic proximity Read ↗

Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.