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Article

GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study.

Pharmacological research - 1 Feb 2025

Magavern Emma F, Deshmukh Harshal, Asselin Geraldine, Theusch Elizabeth, Trompet Stella, Li Xiaohui, Noordam Raymond, Chen Y-D Ida, Seeman Teresa E, Taylor Kent D, Post Wendy S, Tardif Jean-Claude, Paul Dirk S, Benjamin Emelia J, Heard-Costa Nancy L, Vasan Ramachandran S, Rotter Jerome I, Krauss Ronald M, Jukema J Wouter, Ridker Paul M, Munroe Patricia B, Caulfield Mark J, Chasman Daniel I, Dubé Marie-Pierre, Hitman Graham A, Warren Helen R

Abstract excerpt

Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin response. CRP statin response is the change in log-CRP between off-treatment and on-treatment measurements....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39798939
DOI: 10.1016/j.phrs.2024.107575
PMCID: PMC13222656

Genes

CRP
APOE
CAD
HNF1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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