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Article

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223.

Nature - 28 Feb 2008

Johnnidis Jonathan B, Harris Marian H, Wheeler Robert T, Stehling-Sun Sandra, Lam Michael H, Kirak Oktay, Brummelkamp Thijn R, Fleming Mark D, Camargo Fernando D

Abstract excerpt

MicroRNAs are abundant in animal genomes and have been predicted to have important roles in a broad range of gene expression programmes. Despite this prominence, there is a dearth of functional knowledge regarding individual mammalian microRNAs. Using a loss-of-function allele in mice, we report here that the myeloid-specific microRNA-223 (miR-223) negatively regulates progenitor proliferation and granulocyte...

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PMID: 18278031
DOI: 10.1038/nature06607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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