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Article

Complexity of miR-223 regulation by CEBPA in human AML.

Leukemia research - 1 May 2010

Eyholzer Marianne, Schmid Sabine, Schardt Julian A, Haefliger Simon, Mueller Beatrice U, Pabst Thomas

Abstract excerpt

microRNA-223 (miR-223) can trigger normal granulopoiesis. miR-223 expression is regulated by two distinct CEBPA (CCAAT/enhancer binding protein-alpha) sites. Here, we report that miR-223 is largely suppressed in cells from acute myeloid leukemia (AML) patients. By sequencing, we found that miR-223 suppression in AML is not caused by DNA sequence alterations, nor is it mediated by promoter hypermethylation. The...

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PMID: 20018373
DOI: 10.1016/j.leukres.2009.11.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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