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Article

Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2012

Yuen Hiu-Fung, Chan Ka-Kui, Grills Claire, Murray James T, Platt-Higgins Angela, Eldin Osama Sharaf, O'Byrne Ken, Janne Pasi, Fennell Dean A, Johnston Patrick G, Rudland Philip S, El-Tanani Mohamed

Abstract excerpt

PURPOSE: Cancer cells have been shown to be more susceptible to Ran knockdown than normal cells. We now investigate whether Ran is a potential therapeutic target of cancers with frequently found mutations that lead to higher Ras/MEK/ERK [mitogen-activated protein/extracellular signal-regulated kinase (ERK; MEK)] and phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 activities. EXPERIMENTAL DESIGN: Apoptosis was...

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Identifiers

PMID: 22090358
DOI: 10.1158/1078-0432.CCR-11-2035
PMCID: PMC3272446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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