Article
Oncogenic synergism between ErbB1, nucleolin, and mutant Ras.
Cancer research - 15 Mar 2011
Farin Keren, Schokoroy Sari, Haklai Roni, Cohen-Or Ifat, Elad-Sfadia Galit, Reyes-Reyes Merit E, Bates Paula J, Cox Adrienne D, Kloog Yoel, Pinkas-Kramarski Ronit
Abstract excerpt
Alterations in the ErbB family of growth factor receptors, their signaling components, and mutational activation of Ras proteins are major contributors to malignant transformation. Recently, mutant Ras was shown to be capable of activating ErbB receptors in a ligand-independent manner. Furthermore, it was observed that nucleolin, a transcriptional regulator and ribosome biogenesis factor, can bind both K-Ras and...
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