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Article

RAN GTPase is an effector of the invasive/metastatic phenotype induced by osteopontin.

Oncogene - 4 Dec 2008

Kurisetty V V, Johnston P G, Johnston N, Erwin P, Crowe P, Fernig D G, Campbell F C, Anderson I P, Rudland P S, El-Tanani M K

Abstract excerpt

Osteopontin (OPN) is a phosphorylated glycoprotein that binds to alpha v-containing integrins and is important in malignant transformation and cancer. Previously, we have utilized suppressive subtractive hybridization between mRNAs isolated from the Rama 37 (R37) rat mammary cell line and a subclone rendered invasive and metastatic by stable transfection with an expression vector for OPN to identify RAN GTPase...

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Identifiers

PMID: 18794800
DOI: 10.1038/onc.2008.325

Genes

RAN

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