Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 ( CDKN1A ) Expression in a p53-Independent Manner

16 Jan 2013

Abstract excerpt

While small-molecule inhibitors of class I/II histone deacetylases (HDAC) have been approved for cancer treatment, inhibitors of the sirtuins (a family of class III HDACs) still require further validation and optimization to enter clinical trials. Recent studies show that tenovin-6, a small-molecule inhibitor of sirtuins SirT1 and SirT2, reduces tumor growth in vivo and eliminates leukemic stem cells in a murine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Histone Deacetylase Inhibitors Research
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23322738
DOI: 10.1158/1535-7163.mct-12-0900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 ( CDKN1A ) Expression in a p53-Independent MannerPMID 23322738Read ↗

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 ActivatorSemantic proximity Read ↗

Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia CellsSemantic proximity Read ↗

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53Semantic proximity Read ↗

Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-κB Pathways.Semantic proximity Read ↗

Suppression of Deacetylase SIRT1 Mediates Tumor-Suppressive NOTCH Response and Offers a Novel Treatment Option in Metastatic Ewing SarcomaSemantic proximity Read ↗

The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell lineSemantic proximity Read ↗

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2Semantic proximity Read ↗

The SIRT2 Pathway Is Involved in the Antiproliferative Effect of Flavanones in Human Leukemia Monocytic THP-1 CellsSemantic proximity Read ↗

The IRF9-SIRT1-P53 axis is involved in the growth of human acute myeloid leukemiaSemantic proximity Read ↗

TP53-agnostic lethality through combined pan-HDAC and CDK inhibition in acute myeloid leukemia.Semantic proximity Read ↗

The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.Semantic proximity Read ↗

NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.