Article
Allelic polymorphism of cytokine genes during pulmonary tuberculosis.
Bulletin of experimental biology and medicine - 1 Aug 2009
Naslednikova I O, Urazova O I, Voronkova O V, Strelis A K, Novitsky V V, Nikulina E L, Hasanova R R, Kononova T E, Serebryakova V A, Vasileva O A, Suhalentseva N A, Churina E G, Kolosova A E, Fedorovich T V
Abstract excerpt
Modern immunological and molecular genetic studies showed that tuberculosis is accompanied by an imbalance in the production of immunoregulatory cytokines by mononuclear leukocytes. T allele and homozygous TT genotype of T-330G polymorphism in the IL2 gene, T allele and TT genotype of C-590T polymorphism in the IL4 gene, and CC genotype of A-1188C polymorphism in the IL12B gene are immunogenetic factors that have...
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