Article
Cytokine gene polymorphisms across tuberculosis clinical spectrum in Pakistani patients.
PloS one - 1 Jan 2009
Ansari Ambreen, Talat Najeeha, Jamil Bushra, Hasan Zahra, Razzaki Tashmeem, Dawood Ghaffar, Hussain Rabia
Abstract excerpt
BACKGROUND: Pakistan ranks 7(th) globally in terms of tuberculosis (TB) disease burden (incidence 181/100000 pop./yr; prevalence of 329/pop./yr). Reports from different populations show variable associations of TB susceptibility and severity with cytokine gene polymorphisms. Tuberculosis clinical severity is multi-factorial and cytokines play a pivotal role in the modulation of disease severity. We have recently...
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